Identification of new bioactive compounds; hyphenated techniques
The second objective of this research line is the identification, characterization and study of the biological activity of diverse natural sources of bioactive compounds with potential application in the treatment or prevention of obesity and its associated comorbidities. These bioactive compounds are of great interest for both the food and the pharmaceutical industry, as they can be the basis for the development of new dietary supplements or functional foods. To this end, activity studies of new extracts or molecules are developed in various models (in vitro, C. elegans, rat / mouse, etc.) in order to select candidates prior to their evaluation in nutritional intervention studies in humans, as well as studying the potential mechanisms involved or their bioavailability.
The main application is:
Development of products with greater efficacy, bioavailability or stability and with fewer side effects than those already known and applicable in diseases related to obesity and their associated metabolic comorbidities (insulin resistance, non-alcoholic fatty liver disease, metabolic syndrome, among others).
Screening of bioactive compounds (cell cultures, Caenorhabditis elegans, rodents)
Studies of mechanisms of action
Studies of efficacy and bioavailability in animal models
Identification of new bioactive compounds useful in the control of body weight and the prevention of obesity and metabolic disturbances:
- able to reduce or delay digestion and absorption of macronutrients.
- with antioxidant and anti-inflammatory properties.
- with lipolytic activity, which directly affect the release of fatty acids from adipose tissue.
- with inhibitory action on adipogenesis, preventing the creation of new adipose tissue and its hypertrophy.
- able to increase energy expenditure, basal metabolism and thermogenesis.
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Journal of Chromatography & Separation Techniques